PSI pre-workout has been scientifically formulated to be one of the most effective non-stim pre-workouts on the market. It contains optimally dosed ingredients that have been extensively studied and proven to synergistically promote vasodilation, enhance nutrient and oxygen delivery to working muscle, and increase cell hydration for incredible pumps while also helping to improve mental focus.

 

But… What is Vasodilation?

The vasodilation process means Nitric Oxide (NO) acts on your blood vessels to dilate, which allows for an increase in blood flow around the body to improve oxygen and nutrient delivery. It also helps delay the effects of fatigue due to the transportation of metabolic waste out of muscle cells - boosting your performance and recovery rate!

For the average person who does not work out, base levels of nitric oxide work just fine. However, for bodybuilders and those who do train, low nitric oxide levels could mean a significant drop in your workout experience, results and recovery.


How Does PSI Promote Vasodilation?

The fast-acting vasodilator formula in PSI contains scientifically proven ingredients such as citrulline malate, arginine, agmatine sulfate, norvaline and beetroot powder. This powerful complex helps increase the production of nitric oxide in the body, which in turn promotes vasodilation to improve blood flow and muscle volumization.

PSI also contains antioxidants and acid buffers including taurine, tyrosine and alpha-ketoglutarate, which will assist you in achieving better focus during your training, improve buffering capacity and enable you to workout harder for longer!

 

How Do I Take PSI?

PSI does not have to be taken on an empty stomach, however it is beneficial to take it 1-2 hours after you have eaten so that it is quickly absorbed. This helps to maximize the effects of this pre-workout.

Take 1 scoop of PSI with 8-10 oz (240-295 mL) water 20 minutes before your workout. As PSI does not contain stimulants, it can be used in the place of stim based pre-workouts if you are training later in the day or at night (less than 5 hours before going to sleep).

Although PSI pre-workout has been formulated as a pre-workout product, the key cognitive ability and mental focus enhancers, along with vasodilators may assist people with cognitive function due to the increase in blood flow and oxygen delivery to the brain.




Looking for a pre-workout with a bit of a stim? Check out how RP Max Pre-Workout can help you supercharge your workout! Click here to find out more




Can I Stack PSI With Other Products?

PSI can be stacked safely with all EHPlabs products, and works optimally when used together with RP Max. This stack will ensure you gain all the benefits of the stimulants and fat burner thermogenics from RP Max, along with the increased blood flow benefits from PSI’s vasodilation nutrient delivery system, contributing to a highly energetic, focused workout along with an increase in muscle volumization and pump.

The PSI and RP Max stack will fine-tune your performance output for each workout, ensuring you are in the optimal physical state to achieve your fitness goals! This combination should only be used in the morning or for lunchtime workouts due to the stim-based nature of RP Max.

Beyond BCAA’s works optimally by taking it either during or post-workout when stacked with PSI - this will help to deliver maximal anti-catabolic effects, improve stamina and muscle protein synthesis. Learn more about Beyond BCAA here >>


Will I Experience Post-Workout Crash with PSI?

PSI should not cause any post-workout crash as it works by increasing blood flow around your body and improving mental focus and cognitive ability. It is also non-stimulatory, so there is very little effect on your adrenal glands and cortisol and should not affect your sleep!


Can I Take PSI For Cardio and Other Sports?

For those who prefer to take their fitness outside the gym in activities such as running or sports, PSI will assist in boosting cognitive ability so you stay focused in whatever you choose to do! It will also help to reduce fatigue and enhance muscular and cardiovascular endurance, as well as boost muscle recovery due to the vasodilator nutrient delivery maximizing nature of the PSI formula.


PSI INGREDIENT PROFILE:

It should be mentioned that PSI pre-workout DOES NOT contain WADA banned substances.

Citrulline Malate – is well known for the pump! It is a well researched pre-workout ingredient that increases levels of arginine in the blood, helps to promote vasodilation by increasing nitric oxide levels, improves buffering capacity by reducing lactate, improves strength training, reduces muscle soreness and enhances recovery.4, 15,17,18

L-Arginine Alpha-Ketoglutarate (1:1) – Arginine is a vasodilator via production of nitric oxide which increases muscle volumization and enhances nutrient and oxygen delivery to your muscles.1 It helps to prevent fatigue allowing you to workout longer.6 Alpha-Ketoglutarate is used by your body to break down fatty acids for energy. It acts as a transporter taking creatine into muscle cells, it decreases lactate in short bouts of exercise, improves oxygen uptake and promotes an anti-catabolic effect after intense exercise.19 In the form of L-Arginine Alpha-Ketoglutarate, it still provides the equivalent amount of both Arginine and Alpha-Ketoglutarate, but has been shown to increase maximal strength in response to training, specifically 1RM.11

Agmatine Sulfate – is a vasodilator due to its effects on the enzyme nitric oxide synthase.10 By increasing vasodilation during training, it can impact muscle protein synthesis.5

Taurine – is a naturally occurring amino acid that is a powerful antioxidant helping to decrease muscle damage and soreness, helps to improve strength levels,8 metabolize fat, promotes insulin sensitivity and blood glucose control,9 improves heart health and helps to improve both mental focus and reaction time.  

L-Tyrosine – is a naturally occurring amino acid that enhances alertness and cognitive performance, especially in demanding situations (eg. heavy workouts), is involved with neurotransmitters and plays a role in the production of epinephrine and dopamine.12 It helps to alleviate stress, and helps with recovery from fatigue without any jittery side effects. When taurine is combined with tyrosine, they work synergistically14 and EHPlabs studies found there is a lift in mood and overall focus.

L-Norvaline – helps to increase levels of arginine in the blood by inhibiting the enzyme that tries to break it down (arginase), leading to increased vasodilation and nutrient delivery to the muscles during training – it also supports the ‘pump’, or muscle volumization.2,13

Beet Root Powder – has antioxidant and anti-inflammatory properties while also containing high levels of nitrates which are converted into nitric oxide in the body.7 This leads to vasodilation of the blood vessels, increased blood flow to the brain, increased nutrient delivery, improves endurance and supports pump. 3,16


REFERENCES:

1. Álvares, T, Conte, C, Paschoalin, V, Silva, J, Meirelles, C, Bhambhani, Y, & Gomes, P (2012), ‘Acute l-arginine supplementation increases muscle blood volume but not strength performance’, Applied Physiology, Nutrition & Metabolism, vol. 37(1), pp. 115

2. Assar, M, Angulo, J, Santos-Ruiz, M, de Adana, J, Pindado, M, Sánchez-Ferrer, A, Hernández, A, & Rodríguez-Mañas, L (2016), ‘ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans’, The Journal of Physiology, Advance online publication. doi:10.1113/JP271836

3. Bailey, S, Varnham, R, DiMenna, F, Breese, B, Wylie, L, & Jones, A (2015), ‘Inorganic nitrate supplementation improves muscle oxygenation, O₂ uptake kinetics, and exercise tolerance at high but not low pedal rates’, Journal of Applied Physiology, vol. 118(11), pp. 1396-1405

4. Bendahan, D, Mattei, J, Confort-Gouny, S, Leguern, M, Musial, C, Alquier, C, & Cozzone, P (2001), ‘31-P MRS analysis of muscle energetics changes associated to citrulline-malate in humans’, Science & Sports fevr, vol. 16(1), pp. 3-9

5. Biolo, G, Tipton, K, Klein, S, & Wolfe, R (1997), ‘An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein’, The American Journal of Physiology, vol. 273(1), pp. 122-129

6. Campbell, B, Roberts, M, Kerksick, C, Wilborn, C, Marcello, B, Taylor, L, Nassar, E, Leutholtz, B, Bowden, R, Rasmussen, C, Greenwood, M, & Kreider, M (2004), ‘Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men’, Nutrition, vol. 22(9), pp. 872-881

7. Clifford, T, Howatson, G, West, D, & Stevenson, E (2015), ‘The potential benefits of red beetroot supplementation in health and disease’, Nutrients, vol. 7(4), pp. 2801-2822

8. da Silva, L, Tromm, C, Bom, F, Mariano, I, Pozzi, B, da Rosa, G, Tuon, T, da Luz, G, Vuolo, F, Petronilho, F, Cassiano, W, De Souza, C, & Pinho, R (2014), ‘Effects of taurine supplementation following eccentric exercise in young adults’, Applied Physiology Nutrition & Metabolism, vol. 39(1), pp. 101-104

9. Ebina, K, Komine, S, Ohno, T, Tokinoya, K, Ishikura, K, Mastui, T, Ra, S, Miyazaki, T, Miyakawa, S, Soya, H & Ohmori, H (2015), ‘Maintenance of blood glucose level during prolonged exercise by taurine supplementation ~Relation to free amino acids and hepatic gluconeogenesis’, Advances in Exercise & Sports Physiology, vol. 21(4), pp. 86

10. Haulică, I, Bild, W, Iliescu, R, Georgescu, R, & Frunză F (1999), ‘Preliminary research on possible relationship of NO with agmatine at the vascular level’, Romanian Journal of Physiology, vol. 36(1), pp. 67-79

11. International Society of Sports Nutrition Conference Proceedings. Sports Nutrition
Review Journal, 1(1):S1-11, 2004.

12. Jongkees, B, Hommel, B, Kühn, S, & Colzato, L (2015), ‘Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review’, Journal of Psychiatric Research, vol. 70, pp. 50-57

13. Kornijchuk, O, Melnyk, O, & Vorobets, Z (2015), ‘SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES’,  Z., vol. 77(6), pp. 3Mikrobiol9-46

14. Pasantes-Morales, H, & Franco, R (2002), ‘Influence of protein tyrosine kinases on cell volume change induced taurine release’, Cerebellum, vol. 1(2), pp. 103-109

15. PÉRE-GUISADO, J, & JAKEMAN, P (2010), ‘CITRULLINE MALATE ENHANCES ATHLETIC ANAEROBIC PERFORMANCE AND RELIEVES MUSCLE SORENESS’, Journal of Strength & Conditioning Research, vol. 24(5), pp. 1215

16. Pinna, M, Roberto, S, Milia, R, Marongiu, E, Olla, S, Loi, A, Migliaccio, G, Padulo, J, Orlandi, C, Tocco, F, Concu, A, & Crisafulli, A (2014), ‘Effect of beetroot juice supplementation on aerobic response during swimming’, Nutrients, vol. 6(2), pp. 605-615

17. Sureda, A, Córdova, A, Ferrer, M, Pérez, G, Tur, J, & Pons, A (2010), ‘L-Citrulline-malate influence over branched chain amino acid utilization during exercise’, European Journal of Applied Physiology, vol. 110(2), pp. 341

18. Wax, B, Kavazis, A, Weldon, K, & Sperlak, J (2015), ‘Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters’, Journal of Strength and Conditioning Research, Vol. 29(3), pp. 786-792

19. Yuefei, L, Lange, R, Langanky, J, Hamma, T, Bingquan, Y, & Steinacker, J (2012), ‘Improved training tolerance by supplementation with α-Keto acids in untrained young adults: a randomized, double blind, placebo-controlled trial’, Journal of the International Society of Sports Nutrition, vol. 9(1), pp. 37

 

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